Rad52 protein inSacchromyces cerevisaeplays an important role indouble-strand break repairby homologous recombination. Rad52 forms heptameric ring that catalyses DNA annealing and mediates Rad51-mediated strand invasion. Rad52 protein also protect 3' single-stranded DNA from exonucleolytic digestion in homologous recombination process.