一旦配体与受体结合,信号就会通过膜传播到细胞质中。以这种方式延续信号称为信号转导。信号转导仅与细胞表面受体一起发生,因为内部受体能够与核中的DNA直接相互作用以启动蛋白质合成(图1)。

From the top, the red sphere named ‘Extracellular Signal Molecule’ is attached to a green chalice-like structure named ‘Receptor Protein’, which lower part is embedded inside a grey horizontal, slightly bent line called ‘plasma membrane of the target cell’. From the bottom of the green structure, the black arrow points down to dark green square, from which another arrow points down to dark green triangle, from which another arrow points down to dark green circle. All dark green structures are named ‘second messengers’. From the dark green circle, black arrow goes through the dark blue, horizontal line separating cytosol from the nucleus and points down towards light blue half-sphere shaped structure named ‘transcription regulatory protein’. Finally, the last black arrow points down to a red box named ‘altered gene expression’ with a fragment of double helix structure under it.

图1:信号转导级联反应后配体与其在细胞表面上的匹配受体结合后,信号传递到细胞的内部并由第二信使传播。反过来,这些激活效应蛋白(例如转录因子),这些蛋白会诱导细胞基因表达的变化。


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