Human embryonic stem (ES) cells andinduced pluripotent stem (iPS)细胞有类似morphologies. Pluripotent stem cells exhibit spherical, undifferentiated cell morphology with smooth membrane surfaces. They grow in tightly packed colonies that exhibit a high nucleus/cytoplasm ratio with prominent nuclei and well-defined edges.

Figure 1:Pluripotent stem cells growing in a feeder-free culture (A) and in a feeder-dependent culture (B).