Unilamellar vesicles are spherical chambers bounded by a single bilayer composed ofamphiphiliclipids that contain liquid inside (Figure 1). Depending on the diameter, there are different types of vesicles:

• Small unilamellar vesicles (SUV):直径范围是15 - 100海里。

• Large unilamellar vesicles (LUV): diameter range is 100 nm-1 µm.

• Giant unilamellar vesicles (GUV): diameter range is 1-100 µm.

Due to their conformation, unilamellar vesicles have become a widely used model of membrane systems with several applications, such as the study of membrane integrity and transmembrane proteins, or drug delivery research.

Figure 1. Unilamellar vesicle schematic diagram.