Think of tumor suppressors as the brakes that preventcancerdevelopment andoncogenesas the gas pedal that accelerates cancer development.BRCA1/2are tumor suppressors, along with many other examples such asP53,PTEN,RB,APC, and others.

There are several功能of tumor suppressor genes, such as ensuring the cell cycle controls and checkpoints, repairing DNA damage, promoting apoptosis, and preventing epithelial to mesenchymal transitions (EMT). Thedeactivationof tumor suppressor gene may lead to the formation of tumor.