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About Viral Gene Therapy:Use DNA to prevent heart failure虚拟实验室模拟
使用病毒作为一种疗法的一种形式，对您来说像科幻小说吗？这可能令人惊讶，但实际上是一种用于将功能基因输送到患者的上升技术。在病毒基因疗法模拟中，您将了解修饰病毒的使用以及如何为其配备治疗基因。利用该领域最近令人兴奋的研究结果，并试图开发潜在的心力衰竭治疗方法。您是否可以设计可以帮助患者心力衰竭的病毒？
Using viruses to cure heart failure
The student will attend a seminar highlighting the causes and symptoms of heart failure, and will have to use gene therapy as a promising way for a treatment based on a particular gene. The student will learn the principles behind the concept of gene therapy and pseudovirus production, and apply them to the present study case of heart failure.
Pseudovirus production and testing
该学生将使用小鼠进行健身测试，以验证基因作为基因治疗的治疗靶点。接下来，他们将必须通过转染相关质粒来产生含有治疗基因的病毒式衣壳，并通过电子显微镜观察它们。最后，将再次在小鼠上测试产生的病毒的效率。由于这是一个虚拟实验室，因此在本实验中不会损害真正的动物，并且与预期的5周孵育相比，结果可立即获得。
Test your gene therapy treatment
Once you have designed your gene therapy treatment and produced your viruses containing a therapeutic gene, it will be time to test it on mice affected with heart failure. Will you be able to find a cure for this genetic condition?
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利用该领域最近令人兴奋的研究结果，并试图开发潜在的心力衰竭治疗方法。Will you be able to design a virus to help revert heart failure in patients?
实验室中的技术
- Co-transfection of mammalian cells
- Viral vector production
- Electron microscopy
Learning Objectives
At the end of this simulation, you will be able to…
- Explain the use of gene therapy for the treatment of heart failure
- 解释心力衰竭的原因
- Design a viralmediated gene therapy approach
- 定义“治疗基因”
- Describe the anatomy and function of the heart from a healthy person vs. a heart failure patient
- 产生ReplicationDeefextive重组腺关系病毒（RAAV）
Simulation Features
长度- 37分钟
Languages– English
Examples of Related Standards
大学
生命科学与第二年有关
NGSS
No direct alignment
IB
B.4 Medicine
AP
No direct alignment
Screenshots of Viral Gene Therapy:Use DNA to prevent heart failure虚拟实验室模拟
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