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关于骨骼肌：Learn about the muscles we use to walk and runVirtual Lab Simulation
您是否曾经想过步行和跑步之间的区别是什么？在此模拟中，您将学习步行过程中使用的肌肉与冲刺的肌肉之间的关键差异。发现这些差异将需要使用各种实验室技术。
Stain two muscles using histochemistry
With a cryostat you will cut two muscles in thin slices, and use different protocols to stain the muscle cells and identify myosin ATPase, succinate dehydrogenase (SDH), and aGDPH. You will dye the cells of the extensor digitorum longus (EDL), as well as those of the soleus to inspect the fibre composition under a light microscope. You will then complete a full protocol. First, you will dissect a rat to extract two types of skeletal muscle. Then, you will use the microtome in a cryostat to prepare microscope slides with the muscles to compare them and inspect the differently stained muscle fibres.
Use the force… transducer!
在模拟的后半部分，您将研究两种类型的骨骼肌的特性，以了解它们的区别以及它们相似的地方。使用力传感器研究两种肌肉的张力如何随长度而异，以及它们以不同的长度和不同刺激产生的力。潜入骨骼肌运动，例如抽搐动力学，破伤风动力学，力频率和疲劳！
Compare the muscles
Use histochemistry and force transduction to get data to compare two types of skeletal muscles from dissected virtual rats. Will you be able to compare the two skeletal muscles and explain why you can be super fit for long walks but get tired from a short sprint?
现在就开始
Investigate the properties of two types of skeletal muscle and analyze their fiber composition. Use histochemistry and force transduction to compare muscles and learn why you can stay energized on long walks but get tired from a short sprint.
技术in Lab
- 组织化学
- 染色/显微镜
- Slide preparation
- 力转导
- 长度张力
- Twitch kinetics
- 破伤风动力学
- 力频率
- 疲劳
学习目标
At the end of this simulation, you will be able to…
- Explain the length-tension relationship in skeletal muscle
- Understand how twitch and tetanus, the force-frequency relationship, and the response
疲劳在不同类型的肌肉方面有所不同 - Measure the physiological properties of isolated EDL and soleus muscles
- Learn about enzyme histochemistry techniques and understand the steps involved
- Quantify the proportion of different fiber types found in both muscle types
仿真功能
Length– 48 minutes
语言- 英语
Examples of Related Standards
University
生活科学与第一年和第二年有关
NGSS
潜在的HS-LS1-2，但是可能太高
IB
11.2 Movement
AP
没有直接对齐
Screenshots of Skeletal Muscle:Learn about the muscles we use to walk and runVirtual Lab Simulation
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